Toxicology Pathology Podcasts
Most of you have probably already heard about the TXP podcasts. But did you already tried one? Podcasts are prepared for one article from each of the issues Toxicologic Pathology. Three Podcast Manager (Dr. Liz McInnes from Syngenta, Dr. Tracy Carlson from Charles River and Dr. Charles Wood from Boehringer Ingelheim) are in charge of selecting an article and make an insightful interview of one of the authors. The questions help the authors bringing a live perspective on their work and complementary information. It’s a cool way to stay tuned on scientific subjects in your car, while cooking or taking a bath!
Keep checking this space for webinar recordings.
BSTP/STP - Carcinogenesis Webinar - 27th October 2020 - CLICK HERE to access the recording.
BSTP/STP - Respiratory Webinar - 10th November 2020 - CLICK HERE to access the recording.
BSTP/STP - Pathology of Mice with Humanised Immune Systems Webinar - 8th December 2020 - CLICK HERE to access the recording.
BSTP/STP - The Fog Dissipates: Insight Into Pulmonary Effects of Vaping - 25th May 2021 - CLICK HERE to access the recording.
BSTP/STP - A Pathologist Perspective on the Non-Clinical Safety Assessment of GalNAc-conjugated RNAi Therapeutics - 8th September 2021 - CLICK HERE to access the recording.
BSTP/STP - The Risk Based Approach to Nonclinical Development of Cellular Therapies - 27th September 2022 - CLICK HERE to access the recording.
BSTP/STP - Overview and Derisking of Findings Associated With the Intrathecal Administration of Antisense Oligonucleotides in Nonhuman Primates - 13th December 2022 - CLICK HERE to access the recording.
BSTP/STP - Anatomy, Physiology & Pathology of the Auditory System - 19th September 2023 - CLICK HERE to access the recording.
Registration to take part in the webinars is free with the dial in details provided at least one week prior to the date of the webinar.
For confidentiality reasons if you are not a member of the BSTP or any other recognised pathology society but, you are a veterinary student or resident, or an early career pathologist you will be required to provide written confirmation of your status from your Head of Department (on headed paper) before you are sent the dial in information.
Webinar Dates 2023:
BSTP/STP Webinar - 3rd October 2023
11:00 AM EDT | 4:00 PM BST | 5:00 PM CEST
Mouse Kidney Parvovirus: Discovery of a Novel Pathogen of Laboratory Mice and Characterization of its Impact on Research
We invite you to participate in a BSTP webinar in collaboration with the Society of Toxicologic Pathology (STP) on Tuesday, 3rd October 2023, from 11:00 AM–12:30 PM Eastern Daylight Time (New York, GMT-4), 4:00–5:30 PM British Summer Time (London, GMT+1).
Registration is required.
Speakers: Sara Santagostino, DVM, PhD, DACVP, Principal Pathologist-Scientist, Genentech Inc; and Sébastien Monette, DVM, MVSc, DACVP, Comparative Pathologist, Memorial Sloan Kettering Cancer Center
Abstract: In 2018, Mouse kidney parvovirus (MKPV) was discovered and determined to be the etiology of murine inclusion body nephropathy (IBN), a condition of previously unknown etiology that had been observed in laboratory mice for over 4 decades by pathologists. The virus was subsequently found globally in laboratory mouse colonies with a prevalence of 9%. MKPV causes a chronic infection with viral replication predominantly occurring in renal tubular epithelium and shedding in urine. In highly immunocompromised mice, IBN can progress to marked renal lesions, renal failure and mortality, whereas in immunocompetent mice the infection causes mild lesions and remains subclinical. Experimental infection studies have shown strain differences in shedding kinetics between immunocompetent inbred C57BL/6NCrl (B6) and outbred Crl:CD1(ICR) mice, and highly immunocompromised NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice, which have implication for diagnostic testing strategies of mouse colonies. To study the impact of MKPV infection on research outcomes, experimentally infected and uninfected B6 and NSG mice we used in pharmacokinetic (PK) studies of two renally excreted drugs, and infected and uninfected B6 mice were used to model chronic kidney disease (CKD) with the adenine diet model, followed by evaluation of anatomic and clinical pathology endpoints of renal structure and function. MKPV infection did not result in significant alterations of PK parameters. In the CKD model, infection significantly altered the severity of interstitial lymphoplasmacytic infiltrates and fibrosis. MKPV should be excluded from immunodeficient mouse colonies because of its potential to induce morbidity and mortality. In light of findings on its effects on the research outcome of a model of CKD in immunocompetent mice, MKPV infection may confound results of kidney disease research performed in mice, and MKPV status should be determined and reported in such studies.
We look forward to your participation.
BSTP/STP Webinar - 12th December 2023
Speakers and topics to be confirmed.
Details of two more webinars taking place in 2023 will be available in due course.
If you would like your details adding to the mailing list or have any queries regarding webinars that the BSTP are involved in, please contact the BSTP Secretariat - email@example.com