Registration to take part in some of these webinars is free with the dial in details provided at least one week prior to the date of the webinar.
For confidentiality reasons if you are not a member of the BSTP or any other recognised pathology society but, you are a veterinary student or resident, or an early career pathologist you will be required to provide written confirmation of your status from your Head of Department (on headed paper) before you are sent the dial in information.
Where available, recordings of webinars are available in the members only area of the BSTP website.
BSTP/STP - Translation of Nonclinical to Clinical Safety Findings for 27 Biotherapeutics - 10th December 2024
BSTP/STP - Assessment of molecular pathways associated with AAV-induced DRG toxicity in mice and monkeys offers opportunity for potential biomarker development - 19th March 2024
BSTP/STP - Anatomy, Physiology & Pathology of the Auditory System - 19th September 2023
BSTP/STP - Overview and Derisking of Findings Associated With the Intrathecal Administration of Antisense Oligonucleotides in Nonhuman Primates - 13th December 2022
BSTP/STP - The Risk Based Approach to Nonclinical Development of Cellular Therapies - 27th September 2022
BSTP/STP - The Fog Dissipates: Insight Into Pulmonary Effects of Vaping - 25th May 2021
BSTP/STP - Pathology of Mice With Humanised Immune Systems - 8th December 2020
BSTP/STP - Respiratory Webinar - 10th November 2020
BSTP/STP - Carcinogenesis Webinar - 27th October 2020
Webinar Dates:
| BSTP/STP Webinar Utilizing Controls to Contextualize Neuropathology Findings in Nonclinical Studies March 25, 2025 11:00 AM EDT | 3:00 PM GMT | 4:00 PM CETWe invite you to participate in a BSTP webinar in collaboration with the Society of Toxicologic Pathology (STP) on Tuesday, March 25, 2025, from 11:00 AM–12:00 PM Eastern Daylight Time (New York, GMT-4), 3:00–4:00 PM British Time (London, GMT), 4:00 PM – 5:00 PM Central European Time (Paris, GMT+1). Speaker: Joy Gary, DVM, PhD, DACVP, Senior Pathologist, StageBio, Mount Jackson, VA Abstract: Careful consideration of microscopic findings in the central nervous system (CNS) of control animals can help to establish background levels of these findings in nonclinical studies. For example, glial reactions can be found in control animals at varying levels across species and in different regions of the CNS. To establish and characterize the frequency of glial reactions in rats and nonhuman primates in the CNS, historical control databases from two different contract research organizations were queried. In rats, glial reactions were mostly minimal to mild (Grade 1 to 2) and were observed most frequently in the cerebral cortex, medulla oblongata, and pons. Microgliosis, as determined by ionized calcium-binding adaptor molecule 1 (IBA1) immunohistochemistry, was the most common glial diagnosis. Control nonhuman primates had more frequent diagnoses of glial reactions, specifically microgliosis, and minimal microgliosis was most common in the white matter (forebrain), medulla oblongata, and cerebellum. Minimal to mild microgliosis was observed for both species in the spinal cord, most commonly in the cervical and thoracic dorsal and lateral tracts. Another example finding in controls suggesting a background or procedure-related change was random, rare apoptosis/single cell necrosis. Very rare cells with morphologic features of apoptosis or single cell necrosis were present in both controls and in treatment groups in nonhuman primate studies involving the administration of biologics. A consistent feature of these studies, cold shock due to ice-cold PBS perfusion and post-necropsy immersion in cold PBS, was proposed as a possible mechanism. These examples highlight the importance of carefully evaluating control animals microscopically, and the importance of reviewing historical control databases. We look forward to your participation.
|
If you would like your details adding to the mailing list or have any queries regarding webinars that the BSTP are involved in, please contact the BSTP Secretariat -bstpsecretariat@gmail.com
IATP/BSTP Webinars
Dates are still pending for two more webinars: AAV-mediated hepatotoxicity, translational aspects (Speakers Basel Assaf and Larissa Mege (Sanofi) and a webinar on NASH (Speaker Michele Vacca (University of Bari)) .
If you would like your details adding to the mailing list or have any queries regarding webinars that the BSTP are involved in, please contact the BSTP Secretariat -bstpsecretariat@gmail.com
ESTP/SFTP/BSTP/ECVP/ESVP Webinars
If you would like your details adding to the mailing list or have any queries regarding webinars that the BSTP are involved in, please contact the BSTP Secretariat - bstpsecretariat@gmail.com
This is a pilot FDA program recommended for all members of the BSTP: Guidance Snapshots.
The WSI and Peer Review guidance's are discussed in podcasts by Lynda Lanning - a long time member of the STP.
(Official caveat- Guidance Snapshots are a communication tool and are not a substitute for the guidance document.)
