The 35th Annual Scientific Meeting of the BSTP – Pathology of Humanised Mouse Models
12th - 13th November 2020
Immunodeficient mice reconstituted with a human immune system are increasingly used for modelling the human immune compartment in numerous preclinical applications, such as adoptive cell therapy and immuno-oncology studies. With the advent of new Advanced Therapy Medicinal Products, humanised mice are likely to become more and more a key component of efficacy and safety assessment in preclinical programmes, including GLP studies. However, limited information is available concerning the morphological aspects of human cell engraftment and the spectrum of spontaneous and experimentally-induced histopathological lesions occurring in these mice.
CLICK HERE for more details