Han Wistar Rat, 92 weeks
Carcinogenicity study; Large mass on dorsal forelimb in control animal; vimentin +ve, actin, desmin and S100 –ve; PTAH -ve
This is an unencapsulated subcutaneous expansile mass infiltrating muscle. It is very cellular consisting of spindle shaped cells with an indistinct eosinophilic cytoplasm with a criss-crossing pattern of growth and a high mitotic rate. There are areas of necrosis.
The interstitial material appears to be collagen. There is no evidence of muscle differentiation. The lack of a storiform pattern of growth and giant cells tends to exclude malignant fibrous histiocytoma.
fibrosarcoma; histiocytic sarcoma; malignant fibrous histiocytoma; rhabdomyosarcoma
Fibrosarcoma
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Last update: 20 October 2008
BRITISH SOCIETY OF TOXICOLOGICAL PATHOLOGISTS
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Copyright © BSTP 2008
