The 36th Annual Scientific Meeting of the BSTP – Pathology of mice with human immune systems (HIS mice)
Wednesday 10th – Friday 12th November 2021
12.30 – 16.30 (GMT+0, London/UCT+0)
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The 36th ASM will be held as a virtual event using Zoom on the afternoons of Wednesday 10th, Thursday 11th and Friday 12th November 2021, from 12.30 – 16.30 (GMT+0, London/UCT+0) each day.
Immunodeficient mice reconstituted with a human immune system are increasingly used for modelling the human immune compartment in numerous preclinical applications, such as adoptive cell therapy and immuno-oncology studies. With the advent of new Advanced Therapy Medicinal Products, humanised mice are likely to become more and more a key component of efficacy and safety assessment in preclinical programmes, including GLP studies. However, limited information is available concerning the morphological aspects of human cell engraftment and the spectrum of spontaneous and experimentally-induced histopathological lesions occurring in these mice.
Working with the Pathological Society of Great Britain and Ireland the meeting will cover the main features of the different humanised mouse platforms; their experimental applications in drug development, oncology and gene and cell therapies; specific safety and regulatory considerations; and future promise and remaining challenges.
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