The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions) is a joint initiative of the STP, ESTP, BSTP and JSTP to develop an internationally accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals.

The Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System is now available - to access a copy, login to the members only area of the BSTP website and click on INHAND

The non-rodent species documents are progressing into membership review.

Because the various rodent systems have been published over several years, some common terms used in pathology were not consistent across the organ systems.  For example, some systems used “thrombus” and some used “thrombosis”.  The Global Editorial and Steering Committee (GESC) undertook a comprehensive review across all rodent organ systems.  Modifications to provide better consistency were recommended and reviewed by the rodent organ working groups.  In addition, an effort was made to harmonize with the ongoing SEND (Standard for Exchange of Nonclinical Data) initiative with the FDA.

The updates to the terms across all rodent organ systems can be seen by accessing goRENI then by clicking on the “Post-publ. changes” under “goRENI members” on the left side of the page.

If you need assistance with access to the goRENI system, please contact Rupert Kellner (rupert.kellner@item.fraunhofer.de).

If you have comments you would like to convey directly to the GESC, please contact the chair of the Charlotte Keenan (charlotte.keenan@msn.com).

Toxicologic Pathology is pleased to announce the publication of a special 2021 issue focusing on Digital Pathology, Tissue Image Analysis, Artificial Intelligence, and Machine Learning in the context of Toxicologic Pathology and Drug Development. This collection of peer-reviewed original research articles and reviews will address multiple topics required for proficiency in these fields.

Toxicologic Pathology is pleased to announce the publication of a special 2020 issue focusing on The Challenges of Inhaled Biotherapeutics. This peer-reviewed issue will bring together experts in the field of inhalation toxicology and pathology to provide an overview of the commonly encountered challenges associated with inhaled biologics. This issue will be forwarded by two white papers–the first addressing the pathological effects commonly seen with inhaled biologics and their implications for drug development, and the second addressing the toxicological and technical challenges associated with this route of delivery.

CLICK HERE for more information.

This call for papers seeks manuscripts from authors with experience in inhalation toxicology or the nonclinical development of inhaled biologics.

Toxicologic Pathology is pleased to announce the publication of a special 2020 issue focusing on Stem Cell-based Therapy Development. Rapid advances in stem cell biology have produced confusion and misinformation on the readiness of this field for clinical use in humans and animals. This peer reviewed special issue will emphasize the issues concerning cell therapies, exemplified but not limited to stem cell and related fields. Major focus will be safety assessment, issues complicating nonclinical  development of stem cell therapies, including study design, methods for evaluating histopathology findings, carcinogenicity evaluation, immune compatibility, and solutions to these issues to propel the field into the future therapies. This issue will explore concepts such as the fate of injected stem cells, teratoma formation and neoplasia, ectopic growths, use of autologous induced stem cells, use of stem cells in veterinary medicine and present state of the field. Also included will be issues of terminology and standardization of methods and nomenclature.

CLICK HERE for more information.

The EPSR Co-ordinator would like to thank everyone who has registered by returning their EPSR Website Access T&Cs. If this is still on your to do list, the form is available in the EPSR section in the members only area of the website.

Also available is a filterable Excel spreadsheet containing the species, tissue and finding of each EPSR case for ease of identifying lesions of interest and we are now able to share the original case descriptions and discussions if any more detail is required on any of the cases in the EPSR archive.

I hope you agree that this is an exciting offering from the BSTP that will benefit all our members as well as enhancing future Webinars, Continuing Education Symposia and Annual Scientific Meetings, where we can also make use of this facility to share scanned slides. New cases for future use are always very welcome so if you have any interesting or unusual lesions or cases please contact the EPSR Co-ordinator via the BSTP Secretariat.