Toxicologic Pathology, the official journal of the Society of Toxicologic Pathology (STP), European Society of Toxicologic Pathology (ESTP) and the British Society of Toxicological Pathologists (BSTP), is currently welcoming applications for the Editor-in-Chief of Toxicologic Pathology. The current editor, Dr. Susan Elmore, concludes her term on December 31, 2020. To ensure a smooth transition, the societies seek to appoint a successor editor by July, 2020.

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The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions) is a joint initiative of the STP, ESTP, BSTP and JSTP to develop an internationally accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals.

The Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System is now available - to access a copy, login to the members only area of the BSTP website and click on INHAND

The non-rodent species documents are progressing into membership review.

Because the various rodent systems have been published over several years, some common terms used in pathology were not consistent across the organ systems.  For example, some systems used “thrombus” and some used “thrombosis”.  The Global Editorial and Steering Committee (GESC) undertook a comprehensive review across all rodent organ systems.  Modifications to provide better consistency were recommended and reviewed by the rodent organ working groups.  In addition, an effort was made to harmonize with the ongoing SEND (Standard for Exchange of Nonclinical Data) initiative with the FDA.

The updates to the terms across all rodent organ systems can be seen by accessing goRENI then by clicking on the “Post-publ. changes” under “goRENI members” on the left side of the page.

If you need assistance with access to the goRENI system, please contact Rupert Kellner (rupert.kellner@item.fraunhofer.de).

If you have comments you would like to convey directly to the GESC, please contact the chair of the Charlotte Keenan (charlotte.keenan@msn.com).

The RSB Animal Science Group and the Home Office Animal Science Regulation Unit annual Animal Science Meeting is taking place on 6 December 2019.

Who should attend? This meeting is aimed at active researchers, support staff and administrators in animal research.

More information: Details of past meetings are on the RSB website and the deadline for applications is Thursday 31 October. For application details, please contact Harriet McAra at events@rsb.org.uk or on 020 3925 3445.

Toxicologic Pathology is pleased to announce the publication of a special 2021 issue focusing on Digital Pathology, Tissue Image Analysis, Artificial Intelligence, and Machine Learning in the context of Toxicologic Pathology and Drug Development. This collection of peer-reviewed original research articles and reviews will address multiple topics required for proficiency in these fields.

Internship in the Pharmaceutical or (Agro-) Chemical Industry:  Career in Toxicologic Pathology

The ESTP would like to promote young colleagues interested in veterinary pathology to discover toxicologic pathology. Therefore, we are happy to share the possibility to apply for internships in departments of pathology/preclinical development in the pharmaceutical and (agro-) chemical industry as well as in contract research laboratories (CRO's).

• An internship in the industry or a CRO aims to provide an introduction to the toxicological and experimental pathologist's daily duties, i.e. technical, scientific and communication aspects, and an understanding of how pathology data fits into drug/chemical development and safety. The intern might also have the possibility to actively contribute to a short project.

• An internship can for example include the following task and challenges: Exposure to systemic toxicology studies including slide evaluation and review together with an experienced pathologists, efficacy, mechanistic and investigative studies, and data handling experience (comprehensive pathology).

• Internships are offered for the following duration:
  • One-day job shadowing for veterinary students
  • Few weeks to several months for veterinary graduates or students currently in a pathology PhD training or residency program (Important: this type of internship is to date not registered as an official training accepted as resident training for the ECVP board preparation)..

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An official application for an internship generally includes a CV and a letter of motivation. Financial assistance cannot be provided by the ESTP but may be available from the respective company.

For any further information including contacts to laboratories willing to offer internships, please do not hesitate to contact us by email using  the contact tool at https://www.eurotoxpath.org/nextgen/index.php

We currently have vacancies for a pathologist and an epidemiologist to join the UK independent Government advisory Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (COC).

The vacancies have been posted on the Department of Health and Social Care website:

https://www.gov.uk/government/organisations/department-of-health-and-social-care/about/recruitment

The Committee meets three times per year, and while there is no remuneration for these posts, travel and subsistence expenses can be claimed.

More information on the COC can be found on the Committee website:

https://www.gov.uk/government/groups/committee-on-carcinogenicity-of-chemicals-in-food-consumer-products-and-the-environment-coc

Book Review: Toxicologic Pathology, Nonclinical Safety Assessment. 2^nd Edition.

Edited by  PS Sahota, JA Popp, JF Hardisty, C Gopinath, PR Bouchard. CRC Press, 1224 pages, 158 color illustrations, 43 tables, Aug 2018. Hardback version (ISBN  9781498745307).

You need to login to the members only area of the website to read the review - http://www.bstp.org.uk/members-area/members/

Toxicologic Pathology is pleased to announce the publication of a special 2020 issue focusing on The Challenges of Inhaled Biotherapeutics. This peer-reviewed issue will bring together experts in the field of inhalation toxicology and pathology to provide an overview of the commonly encountered challenges associated with inhaled biologics. This issue will be forwarded by two white papers–the first addressing the pathological effects commonly seen with inhaled biologics and their implications for drug development, and the second addressing the toxicological and technical challenges associated with this route of delivery.

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This call for papers seeks manuscripts from authors with experience in inhalation toxicology or the nonclinical development of inhaled biologics.

Toxicologic Pathology is pleased to announce the publication of a special 2020 issue focusing on Stem Cell-based Therapy Development. Rapid advances in stem cell biology have produced confusion and misinformation on the readiness of this field for clinical use in humans and animals. This peer reviewed special issue will emphasize the issues concerning cell therapies, exemplified but not limited to stem cell and related fields. Major focus will be safety assessment, issues complicating nonclinical  development of stem cell therapies, including study design, methods for evaluating histopathology findings, carcinogenicity evaluation, immune compatibility, and solutions to these issues to propel the field into the future therapies. This issue will explore concepts such as the fate of injected stem cells, teratoma formation and neoplasia, ectopic growths, use of autologous induced stem cells, use of stem cells in veterinary medicine and present state of the field. Also included will be issues of terminology and standardization of methods and nomenclature.

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Call for proposals

The Biomedical Research Trust (BRET) is a charity which funds work to improve the care, use and replacement of animals in scientific research and increased public understanding of the role of animals in biomedical research.  Previous projects include schools speaker programmes, education for veterinary students, preparation of on line resources and travel bursaries.

We are inviting proposals for funding further work in two categories :

• Improved public education and understanding of the role of research using animals in the biological sciences, including medical advances
• to promote the use and development of 3Rs methods

Proposals should be brief, explaining how the work meets the aims of BRET, what you plan to do and a breakdown of costs.  Grants are usually up to £5000 but proposals for bigger projects may be considered.

If you would like to discuss an idea before submitting please contact us at bretenquiries@btinternet.com

BRET: Registered charity no 292366