We currently have vacancies for a pathologist and an epidemiologist to join the UK independent Government advisory Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (COC).

The vacancies have been posted on the Department of Health and Social Care website:

https://www.gov.uk/government/organisations/department-of-health-and-social-care/about/recruitment

The Committee meets three times per year, and while there is no remuneration for these posts, travel and subsistence expenses can be claimed.

More information on the COC can be found on the Committee website:

https://www.gov.uk/government/groups/committee-on-carcinogenicity-of-chemicals-in-food-consumer-products-and-the-environment-coc

Book Review: Toxicologic Pathology, Nonclinical Safety Assessment. 2^nd Edition.

Edited by  PS Sahota, JA Popp, JF Hardisty, C Gopinath, PR Bouchard. CRC Press, 1224 pages, 158 color illustrations, 43 tables, Aug 2018. Hardback version (ISBN  9781498745307).

You need to login to the members only area of the website to read the review - http://www.bstp.org.uk/members-area/members/

Toxicologic Pathology is pleased to announce the publication of a special 2020 issue focusing on The Challenges of Inhaled Biotherapeutics. This peer-reviewed issue will bring together experts in the field of inhalation toxicology and pathology to provide an overview of the commonly encountered challenges associated with inhaled biologics. This issue will be forwarded by two white papers–the first addressing the pathological effects commonly seen with inhaled biologics and their implications for drug development, and the second addressing the toxicological and technical challenges associated with this route of delivery.

CLICK HERE for more information.

This call for papers seeks manuscripts from authors with experience in inhalation toxicology or the nonclinical development of inhaled biologics.

Toxicologic Pathology is pleased to announce the publication of a special 2020 issue focusing on Stem Cell-based Therapy Development. Rapid advances in stem cell biology have produced confusion and misinformation on the readiness of this field for clinical use in humans and animals. This peer reviewed special issue will emphasize the issues concerning cell therapies, exemplified but not limited to stem cell and related fields. Major focus will be safety assessment, issues complicating nonclinical  development of stem cell therapies, including study design, methods for evaluating histopathology findings, carcinogenicity evaluation, immune compatibility, and solutions to these issues to propel the field into the future therapies. This issue will explore concepts such as the fate of injected stem cells, teratoma formation and neoplasia, ectopic growths, use of autologous induced stem cells, use of stem cells in veterinary medicine and present state of the field. Also included will be issues of terminology and standardization of methods and nomenclature.

CLICK HERE for more information.

Call for proposals

The Biomedical Research Trust (BRET) is a charity which funds work to improve the care, use and replacement of animals in scientific research and increased public understanding of the role of animals in biomedical research.  Previous projects include schools speaker programmes, education for veterinary students, preparation of on line resources and travel bursaries.

We are inviting proposals for funding further work in two categories :

• Improved public education and understanding of the role of research using animals in the biological sciences, including medical advances
• to promote the use and development of 3Rs methods

Proposals should be brief, explaining how the work meets the aims of BRET, what you plan to do and a breakdown of costs.  Grants are usually up to £5000 but proposals for bigger projects may be considered.

If you would like to discuss an idea before submitting please contact us at bretenquiries@btinternet.com

BRET: Registered charity no 292366

Stay up to date with next-generation multiplex fluorescence immunohistochemistry methods

You are invited to attend a webinar hosted by Alexander Klimowicz, Senior Principal Scientist at Boehringer Ingelheim Pharmaceuticals. This webinar will focus on user experiences with the Ultivue InSituPlex^® fluorescence multiplex IHC platform and provide insight into how this technology can be applied in a research setting to address current challenges, enhance research workflow, and create new opportunities for IHC-based experimentation.

Next-generation multiplex fluorescence immunohistochemistry methods offer new capabilities for scientists to explore the biology of disease within patient tissues. New detection methods based on DNA barcoding of primary antibodies, combined with barcode-specific fluorophores, enable higher-plex assays using standard fluorescence microscopy infrastructure. These methods also have the potential to enable more accurate co-expression analysis, higher-resolution target detection, and streamlined multiplex assay development

Date: June 13, 2019

Time: 9am EDT

Click here for more information and to register your place.

You are reminded that to avoid the late payment fee, please ensure that your payment is received by the BSTP on or before 23.59 on Tuesday 30th April.  Any payments received after 00.01 on 1st May, will automatically include the £25 late payment fee.  For those members subscribing to the journal,  your subscription may be suspended after 1st May until your payment is received.

Several notices have been sent out since January advising that your membership payment would be due for payment on 1st April 2019, and as a reminder the fees are as follows:

£60        - BSTP Member - without Journal

£160      - BSTP Member - with Journal (print and online access, including INHAND Supplements = £60 + £100)

£115      - BSTP Member - with Journal (online access only = £60 + £55)

Please renew online and pay by credit card – the preferred option - to start the renewal process, visit http://www.bstp.org.uk/membership-page/

If you would rather pay by bank transfer, please ensure that payment is made in GBP and that you pay the full amount due within 14 days of the generation of your renewal paperwork.   If you pay by bank transfer from outside the UK, you need to ensure that the BSTP receive the full amount due or add £10 to cover any bank or exchange rate charges.  If you have an automatic bank transfer payment set up to pay the BSTP, you need to remember that you still need to complete the online renewal process so that we have on file the paperwork, both for financial and data protection reasons.

The BSTP are no longer able to accept payments by cheque.

Once the payment has been processed, you will automatically receive confirmation of your renewal, don't forget, to download your own receipt or invoice.  The BSTP Secretariat will be notified of your renewal and unless there are any problems, there will be no need for the Secretariat to contact you to confirm your renewal.

If you have any problems renewing your membership online or your circumstances have changed and you prefer not to renew your membership at this time, please contact the BSTP Secretariat as soon as possible.

Integration of Artificial Intelligence with Digital Pathology: Deployment Considerations & Cases Studies in Pharma

24 April, 2019
7:00 PDT | 10:00 EDT | 15:00 BST | 22:00 CST

PRESENTED BY

Daniel Sutton |  Senior Scientist Pathology Sciences, AstraZeneca, R&D Innovative Medicines, Drug Safety & Metabolism

Hosted by Dr. Kate Lillard Tunstall |  Chief Scientific Officer, Indica Labs, Inc

  Indica Labs - Webinar Announcement (907.4 KiB, 69 hits)

By helping scientists make data-driven decisions faster and more efficiently, artificial intelligence (AI) is revolutionizing drug discovery and development.  Pathology is no exception and the Pathology Sciences team at AstraZeneca in Cambridge UK is leading the charge.  Here, neural networks are being deployed to search digital slides for specific tissue classes, features and pathologies that are not easily quantified using traditional image analysis or are too time-consuming for pathologists to quantify by eye.

While AI holds great promise in pathology, it is key to understand the advantages and limitations of the technology in equal measure, the technical (hardware and software) requirements for different deployments, and financial practicalities.  In this one-hour webinar, Daniel Sutton, Senior Scientist at AstraZeneca, will discuss the deployment of AI within the Pathology Science group including:

• Expertise and technology within the group as it relates to image analysis and AI
• Different deployment models for AI and the vendor selection process
• Selection of projects - when does it make sense to use AI?
• The validation processes
• Four practical use-cases for AI in drug discovery and safety assessment

.

Prior to the main presentation, Dr. Kate Lillard Tunstall will give a brief introduction to Indica Labs’ HALO AI solution, introduce some additional use-cases for AI in pathology, and explain how you can get started with AI today.

Who should attend? This webinar is highly recommended for pathologists and scientists with interest in -

• Artificial intelligence, deep learning, machine learning, convolutional neural networks for pathology tissue classification
• Image analysis for digital pathology
• Drug discovery research using tissues (especially oncology)
• Pre-clinical safety assessment/tox pathology
• Time-savings in pathology evaluations for drug development

.

CLICK HERE to register.

Nominations for the 2019 ACVP Mid-career Awards in Research, Diagnostics, and Education are open.  Please note that nominations  and receipt of these awards are limited to ACVP members in good standing.

  ACVP_2019_-_Mid-Career_Excellence_Award.pdf (680.6 KiB, 102 hits)

Applications may be accessed in the members only section of the ACVP website - https://www.acvp.org/